A connector to the 'What3Words' (http://what3words.com/) service, which represents each 3m by 3m square on earth
             with a unique trio of English-language words.

Fit a threshold regression model based on the first-hitting-time of a boundary by the sample path of a Wiener diffusion process. The threshold regression methodology is well suited to applications involving survival and time-to-event data.

Fit a threshold regression model for Interval Censored Data based on the first-hitting-time of a boundary by the sample path of a Wiener diffusion process. The threshold regression methodology is well suited to applications involving survival and time-to-event data.

Defines the classes used to identify
  outliers (threshing) and compute the number of significant principal
  components and number of clusters (reaping) in a joint application
  of PCA and hierarchical clustering. See Wang et al., 2018,
  <doi:10.1186/s12859-017-1998-9>.

Functions that provide point and interval estimations of optimum thresholds for continuous diagnostic tests. The methodology used is based on minimizing an overall cost function in the two- and three-state settings. We also provide functions for sample size determination and estimation of diagnostic accuracy measures. We also include graphical tools. The statistical methodology used here can be found in Perez-Jaume et al (2017) <doi:10.18637/jss.v082.i04> and in Skaltsa et al (2010, 2012) <doi:10.1002/bimj.200900294>, <doi:10.1002/sim.4369>.

We focus on the diagnostic ability assessment of medical tests when the outcome of interest is the status (alive or dead) of the subjects at a certain time-point t. This binary status is determined by right-censored times to event and it is unknown for those subjects censored before t. Here we provide three methods (unknown status exclusion, imputation of censored times and using time-dependent ROC curves) to evaluate the diagnostic ability of binary and continuous tests in this context. Two references for the methods used here are Skaltsa et al. (2010) <doi:10.1002/bimj.200900294> and Heagerty et al. (2000) <doi:10.1111/j.0006-341x.2000.00337.x>.