Methods for fitting nonstationary Gaussian process models by spatial deformation, as introduced by Sampson and Guttorp (1992) <doi:10.1080/01621459.1992.10475181>, and by dimension expansion, as introduced by Bornn et al. (2012) <doi:10.1080/01621459.2011.646919>. Low-rank thin-plate regression splines, as developed in Wood, S.N. (2003) <doi:10.1111/1467-9868.00374>, are used to either transform co-ordinates or create new latent dimensions.

Numerical quadrature of functions of one variable over a finite
  or infinite interval with double exponential formulas.

Compute degree days from daily min and max temperatures for
    modeling plant and insect development.

Provides tools for estimating the Remaining Useful Life (RUL) of degrading systems using linear mixed-effects models and creating a health index. It supports both univariate and multivariate degradation signals. For multivariate inputs, the signals are merged into a univariate health index prior to modeling. Linear and exponential degradation trajectories are supported (the latter using a log transformation). Remaining Useful Life (RUL) distributions are estimated using Bayesian updating for new units, enabling on-site predictive maintenance. Based on the methodology of Liu and Huang (2016) <doi:10.1109/TASE.2014.2349733>.

Genes that are differentially expressed between two or more experimental conditions can be detected in RNA-Seq. A high biological variability may impact the discovery of these genes once it may be divergent between the fixed effects. However, this variability can be covered by the random effects. 'DEGRE' was designed to identify the differentially expressed genes considering fixed and random effects on individuals. These effects are identified earlier in the experimental design matrix. 'DEGRE' has the implementation of preprocessing procedures to clean the near zero gene reads in the count matrix, normalize by 'RLE' published in the 'DESeq2' package, 'Love et al. (2014)' <doi:10.1186/s13059-014-0550-8> and it fits a regression for each gene using the Generalized Linear Mixed Model with the negative binomial distribution, followed by a Wald test to assess the regression coefficients.