Provides tools for simulating spatially dependent predictors (continuous or binary),
    which are used to generate scalar outcomes in a (generalized) linear model framework. Continuous
    predictors are generated using traditional multivariate normal distributions or Gauss Markov random
    fields with several correlation function approaches (e.g., see Rue (2001) <doi:10.1111/1467-9868.00288>
    and Furrer and Sain (2010) <doi:10.18637/jss.v036.i10>), while binary predictors are generated using
    a Boolean model (see Cressie and Wikle (2011, ISBN: 978-0-471-69274-4)). Parameter vectors 
	exhibiting spatial clustering can also be easily specified by the user.

Monitoring reporting rates of subject-level clinical events (e.g.
  adverse events, protocol deviations) reported by clinical trial sites is an
  important aspect of risk-based quality monitoring strategy. Sites that are 
  under-reporting or over-reporting events can be detected using bootstrap
  simulations during which patients are redistributed between sites. Site-specific
  distributions of event reporting rates  are generated that are used to assign
  probabilities to the observed reporting rates.
  (Koneswarakantha 2024 <doi:10.1007/s43441-024-00631-8>).

Functions for obtaining p-values (for hypothesis tests), confidence intervals, and multivariate confidence sets. In particular, the method is compatible with differentially private dataset, as long as the privacy mechanism is known. For more details, see Awan and Wang (2024), "Simulation-based, Finite-sample Inference for Privatized Data", <doi:10.48550/arXiv.2303.05328>.

Provides some code to run simulations of state-space models, and then
             use these in the Approximate Bayesian Computation Sequential Monte Carlo (ABC-SMC) 
             algorithm of Toni et al. (2009) <doi:10.1098/rsif.2008.0172> and a bootstrap particle
             filter based particle Markov chain Monte Carlo (PMCMC) algorithm 
             (Andrieu et al., 2010 <doi:10.1111/j.1467-9868.2009.00736.x>). 
             Also provides functions to plot and summarise the outputs.