In agricultural, post-harvest and processing, engineering and industrial experiments factors are often differentiated with ease with which they can change from experimental run to experimental run. This is due to the fact that one or more factors may be expensive or time consuming to change i.e. hard-to-change factors. These factors restrict the use of complete randomization as it may make the experiment expensive and time consuming. Split plot designs can be used for such situations. In general model estimation of split plot designs require the use of generalized least squares (GLS). However for some split-plot designs ordinary least squares (OLS) estimates are equivalent to generalized least squares (GLS) estimates. These types of designs are known in literature as equivalent-estimation split-plot design. For method details see, Macharia, H. and Goos, P.(2010) <doi:10.1080/00224065.2010.11917833>.Balanced split plot designs are designs which have an equal number of subplots within every whole plot. This package used to construct equivalent estimation balanced split plot designs for different experimental set ups along with different statistical criteria to measure the performance of these designs. It consist of the function equivalent_BSPD().

Saturation of ionic substances in urine is calculated based on
  sodium, potassium, calcium, magnesium, ammonia, chloride, phosphate, sulfate,
  oxalate, citrate, ph, and urate.  This program is intended for research use,
  only.  The code within is translated from EQUIL2 Visual Basic code based on
  Werness, et al (1985) "EQUIL2: a BASIC computer program for the calculation
  of urinary saturation" <doi:10.1016/s0022-5347(17)47703-2> to R. The Visual
  Basic code was kindly provided by Dr. John Lieske of the Mayo Clinic.

We provide a non-parametric and a parametric approach to investigate the equivalence (or non-inferiority) of two survival curves, obtained from two given datasets. The test is based on the creation of confidence intervals at pre-specified time points.
    For the non-parametric approach, the curves are given by Kaplan-Meier curves and the variance for calculating the confidence intervals is obtained by Greenwood's formula.
    The parametric approach is based on estimating the underlying distribution, where the user can choose between a Weibull, Exponential, Gaussian, Logistic, Log-normal or a Log-logistic distribution. Estimates for the variance for calculating the confidence bands are obtained by a (parametric) bootstrap approach. For this bootstrap censoring is assumed to be exponentially distributed and estimates are obtained from the datasets under consideration.
    All details can be found in K.Moellenhoff and A.Tresch: Survival analysis under non-proportional hazards: investigating non-inferiority or equivalence in time-to-event data <arXiv:2009.06699>.