In breeding experiments, mating environmental (ME) designs are very popular as mating designs are directly implemented in the field environment using block or row-column designs. Here, three functions are given related to three new methods which will generate mating diallel cross designs (Hinkelmann and Kempthorne, 1963<doi:10.2307/2333899>) or mating environmental (ME) designs along with design parameters, C matrix, eigenvalues (EVs), degree of fractionations (DF) and canonical efficiency factor (CEF). Another one function is added to check the properties of a given ME diallel cross design.

Function and support for medication and dosing information extraction from free-text clinical notes. Medication entities for the basic medExtractR implementation that can be extracted include drug name, strength, dose amount, dose, frequency, intake time, dose change, and time of last dose. The basic medExtractR is outlined in Weeks, Beck, McNeer, Williams, Bejan, Denny, Choi (2020) <doi: 10.1093/jamia/ocz207>. The extended medExtractR_tapering implementation is intended to extract dosing information for more tapering schedules, which are far more complex. The tapering extension allows for the extraction of additional entities including dispense amount, refills, dose schedule, time keyword, transition, and preposition.

Simulate Mediterranean forest functioning and dynamics using cohort-based description of vegetation [De Caceres et al. (2015) <doi:10.1016/j.agrformet.2015.06.012>; De Caceres et al. (2021) <doi:10.1016/j.agrformet.2020.108233>].

Simulate forest hydrology, forest function and dynamics over landscapes [De Caceres et al. (2015) <doi:10.1016/j.agrformet.2015.06.012>]. Parallelization is allowed in several simulation functions and simulations may be conducted including spatial processes such as lateral water transfer and seed dispersal.

Run flexible mediation analyses using natural effect models as described in 
  Lange, Vansteelandt and Bekaert (2012) <DOI:10.1093/aje/kwr525>, 
  Vansteelandt, Bekaert and Lange (2012) <DOI:10.1515/2161-962X.1014> 
  and Loeys, Moerkerke, De Smet, Buysse, Steen and Vansteelandt (2013) <DOI:10.1080/00273171.2013.832132>.