Help and demo in Spanish of the orloca package. Ayuda y demo en espanol del paquete orloca. Objetos y metodos para manejar y resolver el problema de localizacion de suma minima, tambien conocido como problema de Fermat-Weber. El problema de localizacion de suma minima busca un punto tal que la suma ponderada de las distancias a los puntos de demanda se minimice. Vease "The Fermat-Weber location problem revisited" por Brimberg, Mathematical Programming, 1, pag. 71-76, 1995. <DOI: 10.1007/BF01592245>.
	     Se usan algoritmos generales de optimizacion global para resolver el problema, junto con el metodo especifico Weiszfeld, vease "Sur le point pour lequel la Somme des distance de n points donnes est minimum", por Weiszfeld, Tohoku Mathematical Journal, First Series, 43, pag. 355-386, 1937 o "On the point for which the sum of the distances to n given points is minimum", por E. Weiszfeld y F. Plastria, Annals of Operations Research, 167, pg. 7-41, 2009. <DOI:10.1007/s10479-008-0352-z>.

An extension to the Regression Modeling Strategies package that
    facilitates plotting ordinal regression  model predictions together with
    confidence intervals for each dependent variable level. 
    It also adds a functionality to plot the  model summary as a modifiable 
    object.

Data input/output functions for data that conform to the
    Digital Imaging and Communications in Medicine (DICOM) standard, part
    of the Rigorous Analytics bundle.

Functions for the input/output and visualization of
    medical imaging data that follow either the 'ANALYZE', 'NIfTI' or 'AFNI'
    formats.  This package is part of the Rigorous Analytics bundle.

Image analysis techniques for positron emission tomography
    (PET) that form part of the Rigorous Analytics bundle.

Clinical reports generated by 'Oncomine Reporter' software contain
    critical data in unstructured PDF format, making manual extraction
    time-consuming and error-prone. 'ORscraper' provides a coherent suite of
    functions to automate this process, allowing researchers to parse
    reports, identify key biomarkers, extract genetic variant tables,
    and filter results. It also integrates with the NCBI 'ClinVar' API 
    <https://www.ncbi.nlm.nih.gov/clinvar/> to enrich extracted data.