This ONEST software implements the method of assessing the pathologist agreement in reading PD-L1 assays (Reisenbichler et al. (2020 <doi:10.1038/s41379-020-0544-x>)), to determine the minimum number of evaluators needed to estimate agreement involving a large number of raters. Input to the program should be binary(1/0) pathology data, where “0” may stand for negative and “1” for positive. Additional examples were given using the data from Rimm et al. (2017 <doi:10.1001/jamaoncol.2017.0013>).

Provide principally an eponymic function that numerically computes 
  the Le Cam's one-step estimator for an independent and identically distributed sample. 
  One-step estimation is asymptotically 
  efficient (see L. Le Cam (1956) <https://projecteuclid.org/euclid.bsmsp/1200501652>) 
  and can be computed faster than the maximum likelihood estimator for large observation 
  samples, see e.g. Brouste et al. (2021) <doi:10.32614/RJ-2021-044>.

Allows code to be run only once on a given computer, using
  lockfiles. Typical use cases include startup messages shown only when a
  package is loaded for the very first time.

We introduce an R function
        one_two_sample() which can deal with one and two (normal)
        samples, Ying-Ying Zhang, Yi Wei (2012) <doi:10.2991/asshm-13.2013.29>. 
        For one normal sample x, the function reports
        descriptive statistics, plot, interval estimation and test of
        hypothesis of x. For two normal samples x and y, the function
        reports descriptive statistics, plot, interval estimation and
        test of hypothesis of x and y, respectively. It also reports
        interval estimation and test of hypothesis of mu1-mu2 (the
        difference of the means of x and y) and sigma1^2 / sigma2^2
        (the ratio of the variances of x and y), tests whether x and y
        are from the same population, finds the correlation coefficient
        of x and y if x and y have the same length.

Performs one-way tests in independent groups designs including homoscedastic and heteroscedastic tests. These are one-way analysis of variance (ANOVA), Welch's heteroscedastic F test, Welch's heteroscedastic F test with trimmed means and Winsorized variances, Brown-Forsythe test, Alexander-Govern test, James second order test, Kruskal-Wallis test, Scott-Smith test, Box F test, Johansen F test, Generalized tests equivalent to Parametric Bootstrap and Fiducial tests, Alvandi's F test, Alvandi's generalized p-value, approximate F test, B square test, Cochran test, Weerahandi's generalized F test, modified Brown-Forsythe test, adjusted Welch's heteroscedastic F test, Welch-Aspin test, Permutation F test. The package performs pairwise comparisons and graphical approaches. Also, the package includes Student's t test, Welch's t test and Mann-Whitney U test for two samples. Moreover, it assesses variance homogeneity and normality of data in each group via tests and plots (Dag et al., 2018, <https://journal.r-project.org/archive/2018/RJ-2018-022/RJ-2018-022.pdf>).