Sigmoidal model fitting, optimal model selection and calculation of various features that are essential in the analysis of quantitative real-time polymerase chain reaction (qPCR), according to Ritz & Spiess (2008) <doi:10.1093/bioinformatics/btn227> and Spiess et al. (2008) <doi:10.1186/1471-2105-9-221>.

Computes normalized cycle threshold (Ct) values (delta Ct) from raw quantitative polymerase 
    chain reaction (qPCR) Ct values and conducts test of significance using t.test(). Plots expression 
    values based from log2(2^(-1*delta delta Ct)) across groups per gene of interest. Methods for calculation
    of delta delta Ct and relative expression (2^(-1*delta delta Ct)) values are described in: 
    Livak & Schmittgen, (2001) <doi:10.1006/meth.2001.1262>.

Content-preserving transformations transformations of PDF files such 
    as split, combine, and compress. This package interfaces directly to the 'qpdf' 
    C++ library <https://qpdf.sourceforge.io/> and does not require any command 
    line utilities. Note that 'qpdf' does not read actual content from PDF files: 
    to extract text and data you need the 'pdftools' package.

Provides functions for estimating ploidy levels and detecting aneuploidy in individuals using 
             allele intensities or allele count data from high-throughput genotyping platforms, including 
             single nucleotide polymorphism (SNP) arrays and sequencing-based technologies. Implements an extended version of the 'PennCNV' 
             signal standardization method by Wang et al. (2007) <doi:10.1101/gr.6861907> for higher ploidy 
             levels. Computes B-allele frequencies (BAF), z-scores, and identifies copy number variation patterns.

Computes noncompartmental pharmacokinetic parameters
 for drug concentration profiles.  For each profile, data
 imputations and adjustments are made as necessary and
 basic parameters are estimated. Supports single dose, multi-dose,
 and multi-subject data.  Supports steady-state calculations
 and various routes of drug administration. See ?qpNCA and vignettes.
 Methodology follows Rowland and Tozer (2011, ISBN:978-0-683-07404-8), 
 Gabrielsson and Weiner (1997, ISBN:978-91-9765-100-4), and
 Gibaldi and Perrier (1982, ISBN:978-0824710422).